Multistep Conformation Selection in Amyloid Assembly.
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ABSTRACT:
SUBMITTER: Hsieh MC
PROVIDER: S-EPMC5709775 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Multistep Conformation Selection in Amyloid Assembly.
Hsieh Ming-Chien MC Liang Chen C Mehta Anil K AK Lynn David G DG Grover Martha A MA
Journal of the American Chemical Society 20171115 47
Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facial complementarity is a critical determinant for amyloid nucleation and structural selection. ...[more]
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