Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC4725763 | biostudies-other | 2016
REPOSITORIES: biostudies-other
Kim HyeongJun H Loparo Joseph J JJ
Nature communications 20160104
SMC (structural maintenance of chromosomes) family members play essential roles in chromosome condensation, sister chromatid cohesion and DNA repair. It remains unclear how SMCs structure chromosomes and how their mechanochemical cycle regulates their interactions with DNA. Here we used single-molecule fluorescence microscopy to visualize how Bacillus subtilis SMC (BsSMC) interacts with flow-stretched DNAs. We report that BsSMC can slide on DNA, switching between static binding and diffusion. At ...[more]