Ontology highlight
ABSTRACT:
SUBMITTER: Murray-Stewart TR
PROVIDER: S-EPMC5711482 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Murray-Stewart Tracy R TR Woster Patrick M PM Casero Robert A RA
The Biochemical journal 20161001 19
The chemically simple, biologically complex eukaryotic polyamines, spermidine and spermine, are positively charged alkylamines involved in many crucial cellular processes. Along with their diamine precursor putrescine, their normally high intracellular concentrations require fine attenuation by multiple regulatory mechanisms to keep these essential molecules within strict physiologic ranges. Since the metabolism of and requirement for polyamines are frequently dysregulated in neoplastic disease, ...[more]