Unknown

Dataset Information

0

Targeting polyamine metabolism for cancer therapy and prevention.


ABSTRACT: The chemically simple, biologically complex eukaryotic polyamines, spermidine and spermine, are positively charged alkylamines involved in many crucial cellular processes. Along with their diamine precursor putrescine, their normally high intracellular concentrations require fine attenuation by multiple regulatory mechanisms to keep these essential molecules within strict physiologic ranges. Since the metabolism of and requirement for polyamines are frequently dysregulated in neoplastic disease, the metabolic pathway and functions of polyamines provide rational drug targets; however, these targets have been difficult to exploit for chemotherapy. It is the goal of this article to review the latest findings in the field that demonstrate the potential utility of targeting the metabolism and function of polyamines as strategies for both chemotherapy and, possibly more importantly, chemoprevention.

SUBMITTER: Murray-Stewart TR 

PROVIDER: S-EPMC5711482 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Targeting polyamine metabolism for cancer therapy and prevention.

Murray-Stewart Tracy R TR   Woster Patrick M PM   Casero Robert A RA  

The Biochemical journal 20161001 19


The chemically simple, biologically complex eukaryotic polyamines, spermidine and spermine, are positively charged alkylamines involved in many crucial cellular processes. Along with their diamine precursor putrescine, their normally high intracellular concentrations require fine attenuation by multiple regulatory mechanisms to keep these essential molecules within strict physiologic ranges. Since the metabolism of and requirement for polyamines are frequently dysregulated in neoplastic disease,  ...[more]

Similar Datasets

| S-EPMC5753667 | biostudies-literature
| S-EPMC5258827 | biostudies-literature
| S-EPMC6538062 | biostudies-literature
| S-EPMC5142754 | biostudies-literature
| S-EPMC4319695 | biostudies-literature
| S-EPMC5429979 | biostudies-literature
| S-EPMC6487480 | biostudies-literature
| S-EPMC6107220 | biostudies-literature
| S-EPMC6195829 | biostudies-literature
| S-EPMC7472741 | biostudies-literature