Ontology highlight
ABSTRACT:
SUBMITTER: Marty R
PROVIDER: S-EPMC5711564 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Marty Rachel R Kaabinejadian Saghar S Rossell David D Slifker Michael J MJ van de Haar Joris J Engin Hatice Billur HB de Prisco Nicola N Ideker Trey T Hildebrand William H WH Font-Burgada Joan J Carter Hannah H
Cell 20171026 6
MHC-I molecules expose the intracellular protein content on the cell surface, allowing T cells to detect foreign or mutated peptides. The combination of six MHC-I alleles each individual carries defines the sub-peptidome that can be effectively presented. We applied this concept to human cancer, hypothesizing that oncogenic mutations could arise in gaps in personal MHC-I presentation. To validate this hypothesis, we developed and applied a residue-centric patient presentation score to 9,176 canc ...[more]