Vascular beds maintain pancreatic tumour explants for ex vivo drug screening.
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ABSTRACT:
SUBMITTER: Bazou D
PROVIDER: S-EPMC5711628 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Vascular beds maintain pancreatic tumour explants for ex vivo drug screening.
Bazou Despina D Maimon Nir N Gruionu Gabriel G Grahovac Jelena J Seano Giorgio G Liu Hao H Evans Conor L CL Munn Lance L LL
Journal of tissue engineering and regenerative medicine 20170912 1
Our understanding of cancer progression or response to therapies would benefit from benchtop, tissue-level assays that preserve the biology and anatomy of human tumours ex vivo. We present a methodology for maintaining patient tumour samples ex vivo for the purpose of drug testing in a clinical setting. The harvested tumour biopsy, excised from mice or patients, is integrated into a support tissue that includes stroma and vasculature. This support tissue preserves tumour histoarchitecture and re ...[more]
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