Body Mass Index Influences the Prognostic Impact of Combined Nuclear Insulin Receptor and Estrogen Receptor Expression in Primary Breast Cancer.
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ABSTRACT:
SUBMITTER: Bjorner S
PROVIDER: S-EPMC5712344 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Body Mass Index Influences the Prognostic Impact of Combined Nuclear Insulin Receptor and Estrogen Receptor Expression in Primary Breast Cancer.
Björner Sofie S Rosendahl Ann H AH Simonsson Maria M Markkula Andrea A Jirström Karin K Borgquist Signe S Rose Carsten C Ingvar Christian C Jernström Helena H
Frontiers in endocrinology 20171128
The prognostic importance of tumor-specific nuclear insulin receptor (InsR) expression in breast cancer is unclear, while membrane and cytoplasmic localization of InsR is better characterized. The insulin signaling network is influenced by obesity and may interact with the estrogen receptor α (ERα) signaling. The purpose was to investigate the interplay between nuclear InsR, ER, body mass index (BMI), and prognosis. Tumor-specific expression of nuclear InsR was evaluated by immunohistochemistry ...[more]
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