Ontology highlight
ABSTRACT:
SUBMITTER: Riera-Borrull M
PROVIDER: S-EPMC5713233 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Riera-Borrull Marta M García-Heredia Anabel A Fernández-Arroyo Salvador S Hernández-Aguilera Anna A Cabré Noemí N Cuyàs Elisabet E Luciano-Mateo Fedra F Camps Jordi J Menendez Javier A JA Joven Jorge J
International journal of molecular sciences 20171028 11
Prevention of the metabolic consequences of a chronic energy-dense/high-fat diet (HFD) represents a public health priority. Metformin is a strong candidate to be incorporated in alternative therapeutic approaches. We used a targeted metabolomic approach to assess changes related to the multi-faceted metabolic disturbances provoked by HFD. We evaluated the protective effects of metformin and explored how pro-inflammatory and metabolic changes respond when mice rendered obese, glucose-intolerant a ...[more]