Benefits of Metformin in Attenuating the Hallmarks of Aging.
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ABSTRACT:
SUBMITTER: Kulkarni AS
PROVIDER: S-EPMC7347426 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Benefits of Metformin in Attenuating the Hallmarks of Aging.
Kulkarni Ameya S AS Gubbi Sriram S Barzilai Nir N
Cell metabolism 20200424 1
Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting effects in the large clinical trial-TAME (targeting aging by metformin). This review focuses on metformin's mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient sensing, enhancing autophagy and ...[more]
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