Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders.
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ABSTRACT:
SUBMITTER: Knabl J
PROVIDER: S-EPMC5713309 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders.
Knabl Julia J Vattai Aurelia A Ye Yao Y Jueckstock Julia J Hutter Stefan S Kainer Franz F Mahner Sven S Jeschke Udo U
International journal of molecular sciences 20171106 11
Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin ...[more]
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