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Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections.


ABSTRACT: Placental macrophages are a heterogenous population of immune cells present throughout pregnancy. They are essential for maintenance of the homeostatic placenta environment and host defense against infections. The characterization of placental macrophages as well as their activation have been limited for a long time by the lack of convenient tools. The emergence of unbiased methods makes it possible to reappraise the study of placental macrophages. In this review, we discuss the diversity and the functions of placental macrophages to better understand their dysfunctions during placental infections.

SUBMITTER: Mezouar S 

PROVIDER: S-EPMC7568513 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Placental macrophages: Origin, heterogeneity, function and role in pregnancy-associated infections.

Mezouar Soraya S   Katsogiannou Maria M   Ben Amara Amira A   Bretelle Florence F   Mege Jean-Louis JL  

Placenta 20201017


Placental macrophages are a heterogenous population of immune cells present throughout pregnancy. They are essential for maintenance of the homeostatic placenta environment and host defense against infections. The characterization of placental macrophages as well as their activation have been limited for a long time by the lack of convenient tools. The emergence of unbiased methods makes it possible to reappraise the study of placental macrophages. In this review, we discuss the diversity and th  ...[more]

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