Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC5714064 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Wang Caiyan C Jia Qian Q Zeng Jianhua J Chen Ran R Xie Wei W
Science advances 20171201 12
The wyosine derivatives present at position 37 in transfer RNAs (tRNAs) are critical for reading frame maintenance. The methyltransferase Trm5a from <i>Pyrococcus abyssi</i> (PaTrm5a) plays a key role in this hypermodification process in generating m<sup>1</sup>G37 and imG2, two products of the wyosine biosynthetic pathway, through two methyl transfers to distinct substrates, but the mechanism is currently unknown. We report two cocrystal structures of PaTrm5a in complex with tRNA<sup>Phe</sup> ...[more]