Ontology highlight
ABSTRACT:
SUBMITTER: Salvino JM
PROVIDER: S-EPMC5714280 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20170318 10
Prostate cancer is the most frequently diagnosed malignancy and the leading cause of cancer related death in men. First line therapy for disseminated disease relies on androgen deprivation, leveraging the addiction of these tumors on androgens for both growth and survival. Treatment typically involves antagonizing the androgen receptor (AR) or blocking the synthesis of androgens. Recurrence is common and within 2-3years patients develop castration resistant tumors that become unresponsive to AR- ...[more]