Ontology highlight
ABSTRACT:
SUBMITTER: Basu A
PROVIDER: S-EPMC4564548 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Basu Arnab A Mills Debra M DM Mitchell Daniel D Ndungo Esther E Williams John D JD Herbert Andrew S AS Dye John M JM Moir Donald T DT Chandran Kartik K Patterson Jean L JL Rong Lijun L Bowlin Terry L TL
The Journal of infectious diseases 20150722
<h4>Background</h4>The current Ebola virus (EBOV) outbreak has highlighted the troubling absence of available antivirals or vaccines to treat infected patients and stop the spread of EBOV. The EBOV glycoprotein (GP) plays critical roles in the early stage of virus infection, including receptor binding and membrane fusion, making it a potential target for the development of anti-EBOV drugs. We report the identification of 2 novel EBOV inhibitors targeting viral entry.<h4>Methods</h4>To identify s ...[more]