Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC5714294 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Science immunology 20170401 10
Type 1 regulatory T (T<sub>R</sub>1) cells are Foxp3<sup>-</sup> interleukin-10 (IL-10)-producing CD4<sup>+</sup> T cells with potent immunosuppressive properties, but their requirements for lineage development have remained elusive. We show that T<sub>R</sub>1 cells constitute the most abundant regulatory population after allogeneic bone marrow transplantation (BMT), express the transcription factor Eomesodermin (Eomes), and are critical for the prevention of graft-versus-host disease. We demon ...[more]