Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC5714294 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Zhang Ping P Lee Jason S JS Gartlan Kate H KH Schuster Iona S IS Comerford Iain I Varelias Antiopi A Ullah Md Ashik MA Vuckovic Slavica S Koyama Motoko M Kuns Rachel D RD Locke Kelly R KR Beckett Kirrilee J KJ Olver Stuart D SD Samson Luke D LD Montes de Oca Marcela M de Labastida Rivera Fabian F Clouston Andrew D AD Belz Gabrielle T GT Blazar Bruce R BR MacDonald Kelli P KP McColl Shaun R SR Thomas Ranjeny R Engwerda Christian R CR Degli-Esposti Mariapia A MA Kallies Axel A Tey Siok-Keen SK Hill Geoffrey R GR
Science immunology 20170401 10
Type 1 regulatory T (T<sub>R</sub>1) cells are Foxp3<sup>-</sup> interleukin-10 (IL-10)-producing CD4<sup>+</sup> T cells with potent immunosuppressive properties, but their requirements for lineage development have remained elusive. We show that T<sub>R</sub>1 cells constitute the most abundant regulatory population after allogeneic bone marrow transplantation (BMT), express the transcription factor Eomesodermin (Eomes), and are critical for the prevention of graft-versus-host disease. We demon ...[more]