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Three distinct developmental pathways for adaptive and two IFN-?-producing ?? T subsets in adult thymus.

ABSTRACT: Murine ?? T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different ?? T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of ?? T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCR? repertoires and exhibit characteristic expression patterns associated with adaptive (??Tn), IFN-?-producing (??T1) and IFN-?/IL-4-co-producing ?? T cells (??NKT). Developmental progression towards both IFN-?-producing subsets can be induced by TCR signalling, and each pathway results in thymic emigration at a different stage. Finally, we show that ??T1 cells are the predominating IFN-?-producing subset developing in the adult thymus. Thus, this study maps out three distinct development pathways that result in the programming of ??Tn, ??T1 and ??NKT cells.

SUBMITTER: Buus TB

PROVIDER: S-EPMC5715069 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus.

Buus Terkild Brink TB Ødum Niels N Geisler Carsten C Lauritsen Jens Peter Holst JPH

Nature communications 20171204 1

Murine γδ T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different γδ T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of γδ T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCRδ repertoires and exhibit characte ...[more]

PMID: 29203769

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Dataset Information

Three distinct developmental pathways for adaptive and two IFN-?-producing ?? T subsets in adult thymus.

Publications

Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus.

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