Development of interleukin-17-producing V?2+ ?? T cells is reduced by ICOS signaling in the thymus.

ABSTRACT: Co-stimulation is an integral part of T cell signaling involved in almost all facets of T cell biology. While much is known about co-stimulation in differentiation and function of conventional ?? T cells, less is known about how co-stimulation affects the development and programming of ?? T cells. In this study, we have investigated the role of inducible T cell co-stimulator (ICOS) on the development of ?? T cells. We show that ICOS is expressed by a population of immature V?2+CD45RBlow ?? T cells predisposed to interleukin-17 (IL-17) production. We found that treatment with ICOS specific antibodies drastically reduces fetal development of IL-17-producing ?? T cells by agonistic actions, and that ICOS deficient mice have a significant increase in the population of IL-17-producing V?2+ ?? T cells in the thymus, spleen, lymph nodes and skin and exhibit exacerbated sensitization responses to 2,4-dinitrofluorobenzene. In conclusion, this study demonstrates that development of IL-17-producing V?2+ ?? T cells is reduced by ICOS signaling in the thymus.

SUBMITTER: Buus TB 

PROVIDER: S-EPMC4991387 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature