Ontology highlight
ABSTRACT:
SUBMITTER: Hartmann BM
PROVIDER: S-EPMC5715119 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nature communications 20171205 1
The risk of emerging pandemic influenza A viruses (IAVs) that approach the devastating 1918 strain motivates finding strain-specific host-pathogen mechanisms. During infection, dendritic cells (DC) mature into antigen-presenting cells that activate T cells, linking innate to adaptive immunity. DC infection with seasonal IAVs, but not with the 1918 and 2009 pandemic strains, induces global RNA degradation. Here, we show that DC infection with seasonal IAV causes immunogenic RIPK3-mediated cell de ...[more]