Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC5716768 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Yu Xiaotang X Zhang Fan F Mao Jun J Lu Ying Y Li Jiazhi J Ma Wei W Fan Shujun S Zhang Chunying C Li Qing Q Wang Bo B Song Bo B Li Lianhong L
Oncotarget 20171024 58
Protein tyrosine phosphatase receptor-type δ (PTPRD) is frequently inactivated in human cancers. This study investigated the role of PTPRD in the regulation of stemness, epithelial-mesenchymal transition (EMT), and migration and invasion in breast cancer cells. <i>In vitro</i>, PTPRD silencing using siRNA enhanced the stem cell-like properties of breast cancer cells, including their mammosphere- and holoclone-forming abilities, and it promoted tumorigenicity <i>in vivo</i>. PTPRD knockdown also ...[more]