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Protein Structure Facilitates High-Resolution Immunological Mapping.

ABSTRACT: Select agents (SA) pose unique challenges for licensing vaccines and therapies. In the case of toxin-mediated diseases, HHS assigns guidelines for SA use, oversees vaccine and therapy development, and approves animal models and approaches to identify mechanisms for toxin neutralization. In this commentary, we discuss next-generation vaccines and therapies against ricin toxin and botulinum toxin, which are regulated SA toxins that utilize structure-based approaches for countermeasures to guide rapid response to future biothreats.

SUBMITTER: Zuverink M

PROVIDER: S-EPMC5717179 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Protein Structure Facilitates High-Resolution Immunological Mapping.

Zuverink Madison M Barbieri Joseph T JT

Clinical and vaccine immunology : CVI 20171205 12

Select agents (SA) pose unique challenges for licensing vaccines and therapies. In the case of toxin-mediated diseases, HHS assigns guidelines for SA use, oversees vaccine and therapy development, and approves animal models and approaches to identify mechanisms for toxin neutralization. In this commentary, we discuss next-generation vaccines and therapies against ricin toxin and botulinum toxin, which are regulated SA toxins that utilize structure-based approaches for countermeasures to guide ra ...[more]

PMID: 29046310

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