Ontology highlight
ABSTRACT:
SUBMITTER: Alfieri C
PROVIDER: S-EPMC5717348 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Open biology 20171101 11
The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators. During the two decades since its discovery, much has been learnt concerning its role in recognizing and ubiquitinating specific proteins in a cell-cycle-dependent manner, the mechanisms governing substrate specificity, the catalytic process of assembling polyubiquitin chains on its target protein ...[more]