Ontology highlight
ABSTRACT:
SUBMITTER: Criado-Marrero M
PROVIDER: S-EPMC5717532 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Criado-Marrero Marangelie M Rein Theo T Binder Elisabeth B EB Porter James T JT Koren John J Blair Laura J LJ
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20180101 1738
Mood disorders affect nearly a quarter of the world's population. Therefore, understanding the molecular mechanisms underlying these conditions is of great importance. FK-506 binding protein 5 (<i>FKBP5</i>) encodes the FKBP51 protein, a heat shock protein 90 kDa (Hsp90) co-chaperone, and is a risk factor for several affective disorders. FKBP51, in coordination with Hsp90, regulates glucocorticoid receptor (GR) activity via a short negative feedback loop. This signalling pathway rapidly restores ...[more]