Ontology highlight
ABSTRACT:
SUBMITTER: Jinwal UK
PROVIDER: S-EPMC2830818 | biostudies-other | 2010 Jan
REPOSITORIES: biostudies-other
Jinwal Umesh K UK Koren John J Borysov Sergiy I SI Schmid Andreas B AB Abisambra Jose F JF Blair Laura J LJ Johnson Amelia G AG Jones Jeffrey R JR Shults Cody L CL O'Leary John C JC Jin Ying Y Buchner Johannes J Cox Marc B MB Dickey Chad A CA
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100101 2
Imbalanced protein load within cells is a critical aspect for most diseases of aging. In particular, the accumulation of proteins into neurotoxic aggregates is a common thread for a host of neurodegenerative diseases. Our previous work demonstrated that age-related changes to the cellular chaperone repertoire contributes to abnormal buildup of the microtubule-associated protein tau that accumulates in a group of diseases termed tauopathies, the most common being Alzheimer's disease. Here, we sho ...[more]