Ontology highlight
ABSTRACT:
SUBMITTER: Larkin J
PROVIDER: S-EPMC5718969 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nature nanotechnology 20170911 12
Compared with conventional methods, single-molecule real-time (SMRT) DNA sequencing exhibits longer read lengths than conventional methods, less GC bias, and the ability to read DNA base modifications. However, reading DNA sequence from sub-nanogram quantities is impractical owing to inefficient delivery of DNA molecules into the confines of zero-mode waveguides-zeptolitre optical cavities in which DNA sequencing proceeds. Here, we show that the efficiency of voltage-induced DNA loading into wav ...[more]