Ontology highlight
ABSTRACT:
SUBMITTER: Pocratsky AM
PROVIDER: S-EPMC5719045 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Pocratsky Amanda M AM Burke Darlene A DA Morehouse Johnny R JR Beare Jason E JE Riegler Amberly S AS Tsoulfas Pantelis P States Gregory J R GJR Whittemore Scott R SR Magnuson David S K DSK
Nature communications 20171206 1
Neural circuitry in the lumbar spinal cord governs two principal features of locomotion, rhythm and pattern, which reflect intra- and interlimb movement. These features are functionally organized into a hierarchy that precisely controls stepping in a stereotypic, speed-dependent fashion. Here, we show that a specific component of the locomotor pattern can be independently manipulated. Silencing spinal L2 interneurons that project to L5 selectively disrupts hindlimb alternation allowing a continu ...[more]