Ontology highlight
ABSTRACT:
SUBMITTER: Teixeira-Silva A
PROVIDER: S-EPMC5719404 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nature communications 20171207 1
Replication requires homologous recombination (HR) to stabilize and restart terminally arrested forks. HR-mediated fork processing requires single stranded DNA (ssDNA) gaps and not necessarily double strand breaks. We used genetic and molecular assays to investigate fork-resection and restart at dysfunctional, unbroken forks in Schizosaccharomyces pombe. Here, we report that fork-resection is a two-step process regulated by the non-homologous end joining factor Ku. An initial resection mediated ...[more]