Ontology highlight
ABSTRACT:
SUBMITTER: Jones CL
PROVIDER: S-EPMC5720355 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Jones Corey L CL Njomen Evert E Sjögren Benita B Dexheimer Thomas S TS Tepe Jetze J JJ
ACS chemical biology 20170801 9
The 20S proteasome is the main protease for the degradation of oxidatively damaged and intrinsically disordered proteins. When accumulation of disordered or oxidatively damaged proteins exceeds proper clearance in neurons, imbalanced pathway signaling or aggregation occurs, which have been implicated in the pathogenesis of several neurological disorders. Screening of the NIH Clinical Collection and Prestwick libraries identified the neuroleptic agent chlorpromazine as a lead agent capable of enh ...[more]