Ontology highlight
ABSTRACT:
SUBMITTER: Oladapo HO
PROVIDER: S-EPMC5720365 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Oladapo Helen O HO Tarpley Michael M Sauer Scott J SJ Addo Kezia A KA Ingram Shalonda M SM Strepay Dillon D Ehe Ben K BK Chdid Lhoucine L Trinkler Michael M Roques Jose R JR Darr David B DB Fleming Jodie M JM Devi Gayathri R GR Williams Kevin P KP
Cancer letters 20170928
Activation of the Hedgehog (Hh) pathway effector GLI1 is linked to tumorigenesis and invasiveness in a number of cancers, with targeting of GLI1 by small molecule antagonists shown to be effective. We profiled a collection of GLI antagonists possessing distinct mechanisms of action for efficacy in phenotypic models of inflammatory and non-inflammatory breast cancer (IBC and non-IBC) that we showed expressed varying levels of Hh pathway mediators. Compounds GANT61, HPI-1, and JK184 decreased cell ...[more]