Ontology highlight
ABSTRACT:
SUBMITTER: Qu C
PROVIDER: S-EPMC5720685 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Qu Chunrong C Ding Mingmin M Zhu Yingmin Y Lu Yungang Y Du Juan J Miller Melissa M Tian Jinbin J Zhu Jinmei J Xu Jian J Wen Meng M Er-Bu Aga A Wang Jule J Xiao Yuling Y Wu Meng M McManus Owen B OB Li Min M Wu Jilin J Luo Huai-Rong HR Cao Zhengyu Z Shen Bing B Wang Hongbo H Zhu Michael X MX Hong Xuechuan X
Journal of medicinal chemistry 20170428 11
Transient receptor potential canonical 3/6/7 (TRPC3/6/7) are highly homologous receptor-operated nonselective cation channels. Despite their physiological significance, very few selective and potent agonists are available for functional examination of these channels. Using a cell-based high throughput screening approach, a lead compound with the pyrazolopyrimidine skeleton was identified as a TRPC6 agonist. Synthetic schemes for the lead and its analogues were established, and structural-activit ...[more]