Ontology highlight
ABSTRACT:
SUBMITTER: Shah P
PROVIDER: S-EPMC5722502 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Shah Palak P Qiang Lei L Yang Seungwon S Soltani Keyoumars K He Yu-Ying YY
Oncotarget 20171029 57
Nucleotide excision repair (NER) is the most versatile DNA repair pathway for removing DNA damage caused by UV radiation and many environmental carcinogens. NER is essential for suppressing tumorigenesis in the skin, lungs and brain. Although the core NER proteins have been identified and characterized, molecular regulation of NER remains poorly understood. Here we show that ubiquitin-specific peptidase 11 (USP11) positively regulates NER by deubiquitinating xeroderma pigmentosum complementation ...[more]