Dataset Information

Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.

ABSTRACT:

Background and aim

The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA).

Patients and methods

HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time.

Conclusion

We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.

SUBMITTER: Nakanishi R

PROVIDER: S-EPMC5722668 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Publications

Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.

Nakanishi Rine R Post Wendy S WS Osawa Kazuhiro K Jayawardena Eranthi E Kim Michael M Sheidaee Nasim N Nezarat Negin N Rahmani Sina S Kim Nicholas N Hathiramani Nicolai N Susarla Shriraj S Palella Frank F Witt Mallory M Blaha Michael J MJ Brown Todd T TT Kingsley Lawrence L Haberlen Sabina A SA Dailing Christopher C Budoff Matthew J MJ

Coronary artery disease 20180101 1

<h4>Background and aim</h4>The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA).<h4>Patients and methods</h4>HIV-infected and uninfected ...[more]

PMID: 28777120

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Dataset Information

Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.

Background and aim

Patients and methods

Conclusion

Publications

Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.

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