Ontology highlight
ABSTRACT:
SUBMITTER: Chouraki V
PROVIDER: S-EPMC5722716 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Chouraki Vincent V Preis Sarah R SR Yang Qiong Q Beiser Alexa A Li Shuo S Larson Martin G MG Weinstein Galit G Wang Thomas J TJ Gerszten Robert E RE Vasan Ramachandran S RS Seshadri Sudha S
Alzheimer's & dementia : the journal of the Alzheimer's Association 20170608 12
<h4>Introduction</h4>The identification of novel biomarkers associated with Alzheimer's disease (AD) could provide key biological insights and permit targeted preclinical prevention. We investigated circulating metabolites associated with incident dementia and AD using metabolomics.<h4>Methods</h4>Plasma levels of 217 metabolites were assessed in 2067 dementia-free Framingham Offspring Cohort participants (mean age = 55.9 ± 9.7 years; 52.4% women). We studied their associations with future demen ...[more]