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Ocrelizumab and Other CD20⁺ B-Cell-Depleting Therapies in Multiple Sclerosis.

ABSTRACT: Selective depletion of CD20⁺ B cells by anti-CD20 monoclonal antibodies as monotherapy in multiple sclerosis (MS) profoundly suppresses acute inflammatory disease activity and signifies an important advance in the treatment of relapsing-remitting MS. Ocrelizumab, a humanized anti-CD20 monoclonal antibody, is also the first proven therapy to lessen disability progression in primary progressive MS-a breakthrough for patients with a disease that had no proven therapy. Ocrelizumab is generally well tolerated, with the most common adverse events experienced being infusion reactions and infections. In ocrelizumab trials in MS a numerical imbalance in the risk of malignancies was observed. In this article, we review advances in anti-CD20 B-cell-depleting biological therapies for MS, including ocrelizumab, rituximab, and ofatumumab.

SUBMITTER: Gelfand JM

PROVIDER: S-EPMC5722762 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Ocrelizumab and Other CD20+ B-Cell-Depleting Therapies in Multiple Sclerosis.

Gelfand Jeffrey M JM Cree Bruce A C BAC Hauser Stephen L SL

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20171001 4

Selective depletion of CD20+ B cells by anti-CD20 monoclonal antibodies as monotherapy in multiple sclerosis (MS) profoundly suppresses acute inflammatory disease activity and signifies an important advance in the treatment of relapsing-remitting MS. Ocrelizumab, a humanized anti-CD20 monoclonal antibody, is also the first proven therapy to lessen disability progression in primary progressive MS-a breakthrough for patients with a disease that had no proven therapy. Ocrelizumab is gene ...[more]

PMID: 28695471

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