Ontology highlight
ABSTRACT:
SUBMITTER: Giltnane JM
PROVIDER: S-EPMC5723145 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Giltnane Jennifer M JM Hutchinson Katherine E KE Stricker Thomas P TP Formisano Luigi L Young Christian D CD Estrada Monica V MV Nixon Mellissa J MJ Du Liping L Sanchez Violeta V Ericsson Paula Gonzalez PG Kuba Maria G MG Sanders Melinda E ME Mu Xinmeng J XJ Van Allen Eliezer M EM Wagle Nikhil N Mayer Ingrid A IA Abramson Vandana V Gόmez Henry H Rizzo Monica M Toy Weiyi W Chandarlapaty Sarat S Mayer Erica L EL Christiansen Jason J Murphy Danielle D Fitzgerald Kerry K Wang Kai K Ross Jeffrey S JS Miller Vincent A VA Stephens Phillip J PJ Yelensky Roman R Garraway Levi L Shyr Yu Y Meszoely Ingrid I Balko Justin M JM Arteaga Carlos L CL
Science translational medicine 20170801 402
Inhibition of proliferation in estrogen receptor-positive (ER<sup>+</sup>) breast cancers after short-term antiestrogen therapy correlates with long-term patient outcome. We profiled 155 ER<sup>+</sup>/human epidermal growth factor receptor 2-negative (HER2<sup>-</sup>) early breast cancers from 143 patients treated with the aromatase inhibitor letrozole for 10 to 21 days before surgery. Twenty-one percent of tumors remained highly proliferative, suggesting that these tumors harbor alterations a ...[more]