Unknown

Dataset Information

0

Receptor Activator of NF-?B Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone.


ABSTRACT: The spleen plays an important role in protective immunity to bloodborne pathogens. Macrophages and dendritic cells (DCs) in the spleen marginal zone capture microbial antigens to trigger adaptive immune responses. Marginal zone macrophages (MZMs) can also act as a replicative niche for intracellular pathogens, providing a platform for mounting the immune response. Here, we describe a role for RANK in the coordinated function of antigen-presenting cells in the spleen marginal zone and triggering anti-viral immunity. Targeted deletion of RANK results in the selective loss of CD169+ MZMs, which provide a niche for viral replication, while RANK signaling in DCs promotes the recruitment and activation of anti-viral memory CD8 T cells. These studies reveal a role for the RANKL/RANK signaling axis in the orchestration of protective immune responses in the spleen marginal zone that has important implications for the host response to viral infection and induction of acquired immunity.

SUBMITTER: Habbeddine M 

PROVIDER: S-EPMC5723674 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone.

Habbeddine Mohamed M   Verthuy Christophe C   Rastoin Olivia O   Chasson Lionel L   Bebien Magali M   Bajenoff Marc M   Adriouch Sahil S   den Haan Joke M M JMM   Penninger Josef M JM   Lawrence Toby T  

Cell reports 20171101 9


The spleen plays an important role in protective immunity to bloodborne pathogens. Macrophages and dendritic cells (DCs) in the spleen marginal zone capture microbial antigens to trigger adaptive immune responses. Marginal zone macrophages (MZMs) can also act as a replicative niche for intracellular pathogens, providing a platform for mounting the immune response. Here, we describe a role for RANK in the coordinated function of antigen-presenting cells in the spleen marginal zone and triggering  ...[more]

Similar Datasets

| S-EPMC5073155 | biostudies-literature
| S-EPMC3428941 | biostudies-literature
| S-EPMC5121635 | biostudies-literature
| S-EPMC3099422 | biostudies-literature
| S-EPMC11001640 | biostudies-literature
| S-EPMC6761012 | biostudies-literature
| S-EPMC3262910 | biostudies-literature
| S-EPMC5649024 | biostudies-literature
| S-EPMC4344459 | biostudies-literature
| S-EPMC7275705 | biostudies-literature