Polymorphisms of the stem cell marker gene CD133 are associated the clinical outcome in a cohort of Chinese non-small cell lung cancer patients.

ABSTRACT: OBJECTIVES:To evaluate the prognostic relevance of four functional single nucleotide polymorphisms (SNPs) in CD133 (rs2240688A>C, rs10022537T>A, rs7686732C>G, and rs3130C>T) on overall survival (OS) of non-small cell lung cancer (NSCLC) patients. DESIGN:Retrospective cohort study. SETTING:Department of General Surgery, in a general hospital, Henan Province, China. PARTICIPANTS:NSCLC patients aged ?18 years, who were not receiving preoperative neoadjuvant therapies and had a blood sample available for genotyping, were eligible for inclusion. Those participants who were pregnant or breastfeeding, had a previous history of cancer, had other primary tumours, or who had had primary tumours of the skin and nasopharynx, were excluded from the study. OUTCOME MEASURES:The primary endpoint was OS, which was calculated from the date of enrolment until the date of death or date of last follow-up. RESULTS:There was a total of 1383 participants, with a median age of 63 years; 726 (52.5%) were male. Compared with thers2240688 AA genotype, the variant AC/CC genotypes were independently associated with OS (HR 1.27, 95% CI 1.12 to 1.45 for AC genotype; HR 2.32, 95%?CI 1.91 to 2.80 for CC genotype). Higher hazard ratios for associations between CD133 rs2240688 polymorphism and OS were observed in patients with adjuvant chemotherapy (HR 1.86, 95%?CI 1.52 to 2.26) and radiotherapy for curative intent (HR 1.90, 95%?CI 1.55 to 2.33). CONCLUSIONS:The study confirmed the significant association between the SNP rs2240688 A>C of CD133 and OS of NSCLC patients. Larger population-based studies in different ethnic groups are necessary to further validate the role and mechanisms of CD133 in NSCLC.

SUBMITTER: Liu QF 

PROVIDER: S-EPMC5724226 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature