Ontology highlight
ABSTRACT:
SUBMITTER: Karbanova J
PROVIDER: S-EPMC2569896 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Karbanová Jana J Missol-Kolka Ewa E Fonseca Ana-Violeta AV Lorra Christoph C Janich Peggy P Hollerová Hana H Jászai József J Ehrmann Jirí J Kolár Zdenek Z Liebers Cornelia C Arl Stefanie S Subrtová Danuse D Freund Daniel D Mokry Jaroslav J Huttner Wieland B WB Corbeil Denis D
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20080721 11
Human prominin-1 (CD133) is expressed by various stem and progenitor cells originating from diverse sources. In addition to stem cells, its mouse ortholog is expressed in a broad range of adult epithelial cells, where it is selectively concentrated in their apical domain. The lack of detection of prominin-1 in adult human epithelia might be explained, at least in part, by the specificity of the widely used AC133 antibody, which recognizes an epitope that seems dependent on glycosylation. Here we ...[more]