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MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women.


ABSTRACT: In this case-control study, we analyzed the association between eight RegulomeDB-annotated single nucleotide polymorphisms (SNPs) in the MEK1, MEK2, ERK1 and ERK2 genes and polycystic ovarian syndrome (PCOS). Logistic regression analysis demonstrated that MEK1 rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], P = 0.012), ERK2 rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], P = 0.040) and ERK2 rs5999521 (OR = 0.66 [95%CI: 0.51-0.86], P = 0.002) were associated with PCOS risk without adjusting for age and body mass index. Moreover, PCOS risk increased with allele dosage when these three polymorphisms were combined (Ptrend = 0.001). These findings suggest that genetic variants in key MAPK and ERK genes contribute to PCOS risk in Chinese women.

SUBMITTER: Hu L 

PROVIDER: S-EPMC5725017 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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<i>MAPK</i> and <i>ERK</i> polymorphisms are associated with PCOS risk in Chinese women.

Hu Lingmin L   Zhang Yiting Y   Chen Li L   Zhou Wei W   Wang Yong Y   Wen Juan J  

Oncotarget 20171027 59


In this case-control study, we analyzed the association between eight RegulomeDB-annotated single nucleotide polymorphisms (SNPs) in the <i>MEK1</i>, <i>MEK2</i>, <i>ERK1</i> and <i>ERK2</i> genes and polycystic ovarian syndrome (PCOS). Logistic regression analysis demonstrated that <i>MEK1</i> rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], <i>P</i> = 0.012), <i>ERK2</i> rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], <i>P</i> = 0.040) and <i>ERK2</i> rs5999521 (OR = 0.66 [95%CI: 0.51-0.86], <i>P</i> = 0.00  ...[more]

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