Ontology highlight
ABSTRACT:
SUBMITTER: Hu L
PROVIDER: S-EPMC5725017 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Hu Lingmin L Zhang Yiting Y Chen Li L Zhou Wei W Wang Yong Y Wen Juan J
Oncotarget 20171027 59
In this case-control study, we analyzed the association between eight RegulomeDB-annotated single nucleotide polymorphisms (SNPs) in the <i>MEK1</i>, <i>MEK2</i>, <i>ERK1</i> and <i>ERK2</i> genes and polycystic ovarian syndrome (PCOS). Logistic regression analysis demonstrated that <i>MEK1</i> rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], <i>P</i> = 0.012), <i>ERK2</i> rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], <i>P</i> = 0.040) and <i>ERK2</i> rs5999521 (OR = 0.66 [95%CI: 0.51-0.86], <i>P</i> = 0.00 ...[more]