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To take or not to take: the association between perceived addiction risk, expected analgesic response and likelihood of trying novel pain relievers in self-identified chronic pain patients.

ABSTRACT: BACKGROUND AND AIMS:Probability discounting refers to the effect of outcome uncertainty on decision making. Using probability discounting, we examined the degree to which self-identified chronic pain patients (CPP) were likely to try a novel analgesic medication given increasing addiction risk. We postulated that propensity for opioid misuse, trait impulsivity and previous opioid experience would be associated positively with likelihood of risky medication use. DESIGN:This cross-sectional on-line study determined state/trait associations with addiction-related medication decisions in CPP. SETTING:US-based CPP participated via Amazon Mechanical Turk; data were collected and analyzed in Baltimore, Maryland. PARTICIPANTS:A total of 263 CPP (70.6% female) participated in the study from 12-13 December 2014. MEASUREMENTS:CPP responded to the Benefit versus Addiction Risk Questionnaire (BARQ) assessing likelihood of taking a hypothetical once-daily oral analgesic medication as a function of two factors: risk of addiction (0-50%) and duration of expected complete pain relief (3, 30 or 365 days). The primary outcome was the BARQ, quantified as area under the curve (AUC). Grouping of CPP at high or low risk for opioid misuse was based on the Screener and Opioid Assessment for Patients with Pain-Revised (SOAPP-R). Predictors included previous experience with opioids, as well as various measures of chronic pain and mental health. FINDINGS:Across hypothetical addiction risk assessed in the BARQ, the likelihood of taking a novel analgesic medication was elevated significantly in patients with high (?18; n = 137) versus low (<18; n = 126) SOAPP-R scores [P < 0.001; 3-day: Cohen's d = 0.66, 95% confidence interval (CI) = 0.63, 0.69; 30-day: d = 0.74, 95% CI = 0.71, 0.78; 365-day: d = 0.75, 95% CI = 0.72, 0.79]. CONCLUSIONS:In the United States, self-identified chronic pain patients (CPP) at higher risk for opioid misuse were more likely to report willingness to try a novel analgesic despite increasing addiction risk than CPP with low risk of opioid misuse.

SUBMITTER: Tompkins DA

PROVIDER: S-EPMC5725253 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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To take or not to take: the association between perceived addiction risk, expected analgesic response and likelihood of trying novel pain relievers in self-identified chronic pain patients.

Tompkins D Andrew DA Huhn Andrew S AS Johnson Patrick S PS Smith Michael T MT Strain Eric C EC Edwards Robert R RR Johnson Matthew W MW

Addiction (Abingdon, England) 20170810 1

<h4>Background and aims</h4>Probability discounting refers to the effect of outcome uncertainty on decision making. Using probability discounting, we examined the degree to which self-identified chronic pain patients (CPP) were likely to try a novel analgesic medication given increasing addiction risk. We postulated that propensity for opioid misuse, trait impulsivity and previous opioid experience would be associated positively with likelihood of risky medication use.<h4>Design</h4>This cross-s ...[more]

PMID: 28645137

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Project description:A large body of evidence shows that interaction with greenery can be beneficial for human stress reduction, emotional states, and improved cognitive function. It can, therefore, be expected that university students might benefit from greenery in the university environment. Before investing in real-life interventions in a university environment, it is necessary to first explore students' perceptions of greenery in the university environment. This study examined (1) preference for university indoor and outdoor spaces with and without greenery (2) perceived restoration likelihood of university outdoor spaces with and without greenery and (3) if preference and perceived restoration likelihood ratings were modified by demographic characteristics or connectedness to nature in Dutch university students (N = 722). Digital photographic stimuli represented four university spaces (lecture hall, classroom, study area, university outdoor space). For each of the three indoor spaces there were four or five stimuli conditions: (1) the standard design (2) the standard design with a colorful poster (3) the standard design with a nature poster (4) the standard design with a green wall (5) the standard design with a green wall plus interior plants. The university outdoor space included: (1) the standard design (2) the standard design with seating (3) the standard design with colorful artifacts (4) the standard design with green elements (5) the standard design with extensive greenery. Multi-level analyses showed that students gave higher preference ratings to the indoor spaces with a nature poster, a green wall, or a green wall plus interior plants than to the standard designs and the designs with the colorful posters. Students also rated preference and perceived restoration likelihood of the outdoor spaces that included greenery higher than those without. Preference and perceived restoration likelihood were not modified by demographic characteristics, but students with strong connectedness to nature rated preference and perceived restoration likelihood overall higher than students with weak connectedness to nature. The findings suggest that students would appreciate the integration of greenery in the university environment.

Dataset Information

To take or not to take: the association between perceived addiction risk, expected analgesic response and likelihood of trying novel pain relievers in self-identified chronic pain patients.

Publications

To take or not to take: the association between perceived addiction risk, expected analgesic response and likelihood of trying novel pain relievers in self-identified chronic pain patients.

Similar Datasets

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