Dataset Information

Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth.

ABSTRACT:

Background

Identification of factors that influence the neonatal gut microbiome is urgently needed to guide clinical practices that support growth of healthy preterm infants. Here, we examined the influence of nutrition and common practices on the gut microbiota and growth in a cohort of preterm infants.

Results

With weekly gut microbiota samples spanning postmenstrual age (PMA) 24 to 46 weeks, we developed two models to test associations between the microbiota, nutrition and growth: a categorical model with three successive microbiota phases (P1, P2, and P3) and a model with two periods (early and late PMA) defined by microbiota composition and PMA, respectively. The more significant associations with phase led us to use a phase-based framework for the majority of our analyses. Phase transitions were characterized by rapid shifts in the microbiota, with transition out of P1 occurring nearly simultaneously with the change from meconium to normal stool. The rate of phase progression was positively associated with gestational age at birth, and delayed transition to a P3 microbiota was associated with growth failure. We found distinct bacterial metabolic functions in P1-3 and significant associations between nutrition, microbiota phase, and infant growth.

Conclusion

The phase-dependent impact of nutrition on infant growth along with phase-specific metabolic functions suggests a pioneering potential for improving growth outcomes by tailoring nutrient intake to microbiota phase.

SUBMITTER: Grier A

PROVIDER: S-EPMC5725645 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Publications

Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth.

Grier Alex A Qiu Xing X Bandyopadhyay Sanjukta S Holden-Wiltse Jeanne J Kessler Haeja A HA Gill Ann L AL Hamilton Brooke B Huyck Heidie H Misra Sara S Mariani Thomas J TJ Ryan Rita M RM Scholer Lori L Scheible Kristin M KM Lee Yi-Horng YH Caserta Mary T MT Pryhuber Gloria S GS Gill Steven R SR

Microbiome 20171211 1

<h4>Background</h4>Identification of factors that influence the neonatal gut microbiome is urgently needed to guide clinical practices that support growth of healthy preterm infants. Here, we examined the influence of nutrition and common practices on the gut microbiota and growth in a cohort of preterm infants.<h4>Results</h4>With weekly gut microbiota samples spanning postmenstrual age (PMA) 24 to 46 weeks, we developed two models to test associations between the microbiota, nutrition and grow ...[more]

PMID: 29228972

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Dataset Information

Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth.

Background

Results

Conclusion

Publications

Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth.

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