Dataset Information

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome.

ABSTRACT: The acquisition and development of the infant microbiome are key to establishing a healthy host-microbiome symbiosis. The maternal microbial reservoir is thought to play a crucial role in this process. However, the source and transmission routes of the infant pioneering microbes are poorly understood. To address this, we longitudinally sampled the microbiome of 25 mother-infant pairs across multiple body sites from birth up to 4 months postpartum. Strain-level metagenomic profiling showed a rapid influx of microbes at birth followed by strong selection during the first few days of life. Maternal skin and vaginal strains colonize only transiently, and the infant continues to acquire microbes from distinct maternal sources after birth. Maternal gut strains proved more persistent in the infant gut and ecologically better adapted than those acquired from other sources. Together, these data describe the mother-to-infant microbiome transmission routes that are integral in the development of the infant microbiome.

SUBMITTER: Ferretti P

PROVIDER: S-EPMC6716579 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Publications

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome.

Ferretti Pamela P Pasolli Edoardo E Tett Adrian A Asnicar Francesco F Gorfer Valentina V Fedi Sabina S Armanini Federica F Truong Duy Tin DT Manara Serena S Zolfo Moreno M Beghini Francesco F Bertorelli Roberto R De Sanctis Veronica V Bariletti Ilaria I Canto Rosarita R Clementi Rosanna R Cologna Marina M Crifò Tiziana T Cusumano Giuseppina G Gottardi Stefania S Innamorati Claudia C Masè Caterina C Postai Daniela D Savoi Daniela D Duranti Sabrina S Lugli Gabriele Andrea GA Mancabelli Leonardo L Turroni Francesca F Ferrario Chiara C Milani Christian C Mangifesta Marta M Anzalone Rosaria R Viappiani Alice A Yassour Moran M Vlamakis Hera H Xavier Ramnik R Collado Carmen Maria CM Koren Omry O Tateo Saverio S Soffiati Massimo M Pedrotti Anna A Ventura Marco M Huttenhower Curtis C Bork Peer P Segata Nicola N

Cell host & microbe 20180701 1

The acquisition and development of the infant microbiome are key to establishing a healthy host-microbiome symbiosis. The maternal microbial reservoir is thought to play a crucial role in this process. However, the source and transmission routes of the infant pioneering microbes are poorly understood. To address this, we longitudinally sampled the microbiome of 25 mother-infant pairs across multiple body sites from birth up to 4 months postpartum. Strain-level metagenomic profiling showed a rapi ...[more]

PMID: 30001516

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Dataset Information

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome.

Publications

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome.

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