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Multiple breath washout testing in adults with pulmonary disease and healthy controls - can fewer measurements eventually be more?

ABSTRACT: Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three technically acceptable measurements according to current recommendations prolongs test times. We therefore aimed to evaluate reporting only duplicate measurements in healthy adults and pulmonary disease.One hundred and fifty-three subjects prospectively underwent conventional lung function testing and closed-circuit SF6-MBW. Three technically acceptable MBW-measurements were obtained in 103 subjects.Lung clearance index (LCI) differed significantly among 19 controls (7.4?±?0.8), 19 patients with sarcoidosis (8.1?±?1.2), 32 with bronchial asthma (9.2?±?1.9) and 33 with COPD (10.8?±?2.2, p 

SUBMITTER: Trinkmann F 

PROVIDER: S-EPMC5725793 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Multiple breath washout testing in adults with pulmonary disease and healthy controls - can fewer measurements eventually be more?

Trinkmann Frederik F   Götzmann Johannes J   Saur Daniel D   Schroeter Michele M   Roth Katharina K   Stach Ksenija K   Borggrefe Martin M   Saur Joachim J   Akin Ibrahim I   Michels Julia D JD  

BMC pulmonary medicine 20171211 1

<h4>Background</h4>Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three technically acceptable measurements according to current recommendations prolongs test times. We therefore aimed to evaluate reporting only duplicate measurements in healthy adults and pulmonary disease.<h4>Methods</h4>One hundred and fifty-three subjects prospectively underwe  ...[more]

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