Ontology highlight
ABSTRACT:
SUBMITTER: Gupta P
PROVIDER: S-EPMC5726394 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Gupta Pulkit P Liu Bo B Klepacki Dorota D Gupta Vrinda V Schulten Klaus K Mankin Alexander S AS Vázquez-Laslop Nora N
Nature chemical biology 20160104 3
Regulation of gene expression in response to the changing environment is critical for cell survival. For instance, binding of macrolide antibiotics to the ribosome promotes translation arrest at the leader open reading frames ermCL and ermBL, which is necessary for inducing the antibiotic resistance genes ermC and ermB. Cladinose-containing macrolides such as erythromycin (ERY), but not ketolides such as telithromycin (TEL), arrest translation of ermCL, whereas either ERY or TEL stall ermBL tran ...[more]