TIM-4 Identifies IFN-γ-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection.

ABSTRACT: B cells give rise to polarized subsets, including B effector 1 (Be1) cells and regulatory B cells, which can promote or inhibit immune responses through expression of IFN-γ and IL-10, respectively. Such subsets likely explain why B cell depletion can either ameliorate or exacerbate inflammatory diseases; however, these cells remain poorly understood because of the absence of specific markers. Although T cell Ig and mucin domain-containing molecule (TIM)-1 broadly identifies IL-10⁺ regulatory B cells, no similar markers for Be1 cells have been described. We now show that TIM-4 is expressed by a subset of B cells distinct from those expressing TIM-1. Although TIM-1⁺ B cells are enriched for IL-10, TIM-4⁺ B cells are enriched for IFN-γ. TIM-1⁺ B cel

SUBMITTER: Ding Q 

PROVIDER: S-EPMC5726915 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature