Ontology highlight
ABSTRACT:
SUBMITTER: von Raußendorf F
PROVIDER: S-EPMC5727165 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
von Raußendorf Freia F de Ruiter Anita A Leonard Thomas A TA
Scientific reports 20171212 1
The Tec kinases, closely related to Src family kinases, are essential for lymphocyte function in the adaptive immune system. Whilst the Src and Abl kinases are regulated by tail phosphorylation and N-terminal myristoylation respectively, the Tec kinases are notable for the absence of either regulatory element. We have found that the inactive conformations of the Tec kinase Itk and Src preferentially bind ADP over ATP, stabilising both proteins. We demonstrate that Itk adopts the same conformatio ...[more]