Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC5727192 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zhang Congcong C Wang Chunxiao C Li Yulin Y Miwa Takashi T Liu Chang C Cui Wei W Song Wen-Chao WC Du Jie J
Nature communications 20171212 1
Regeneration of skeletal muscle following injury is accompanied by transient inflammation. Here we show that complement is activated in skeletal muscle injury and plays a key role during regeneration. Genetic ablation of complement C3 or its inactivation with Cobra Venom Factor (CVF) result in impaired muscle regeneration following cardiotoxin-induced injury in mice. The effect of complement in muscle regeneration is mediated by the alternative pathway and C3a receptor (C3aR) signaling, as delet ...[more]