Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Malpartida P
PROVIDER: S-EPMC5727232 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nature communications 20171212 1
Smad transcription factors activated by TGF-β or by BMP receptors form trimeric complexes with Smad4 to target specific genes for cell fate regulation. The CAGAC motif has been considered as the main binding element for Smad2/3/4, whereas Smad1/5/8 have been thought to preferentially bind GC-rich elements. However, chromatin immunoprecipitation analysis in embryonic stem cells showed extensive binding of Smad2/3/4 to GC-rich cis-regulatory elements. Here, we present the structural basis for spec ...[more]