Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques.
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ABSTRACT:
SUBMITTER: Dudley DM
PROVIDER: S-EPMC5727388 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
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Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques.
Dudley Dawn M DM Newman Christina M CM Lalli Joseph J Stewart Laurel M LM Koenig Michelle R MR Weiler Andrea M AM Semler Matthew R MR Barry Gabrielle L GL Zarbock Katie R KR Mohns Mariel S MS Breitbach Meghan E ME Schultz-Darken Nancy N Peterson Eric E Newton Wendy W Mohr Emma L EL Capuano Iii Saverio S Osorio Jorge E JE O'Connor Shelby L SL O'Connor David H DH Friedrich Thomas C TC Aliota Matthew T MT
Nature communications 20171213 1
Mouse and nonhuman primate models now serve as useful platforms to study Zika virus (ZIKV) pathogenesis, candidate therapies, and vaccines, but they rely on needle inoculation of virus: the effects of mosquito-borne infection on disease outcome have not been explored in these models. Here we show that infection via mosquito bite delays ZIKV replication to peak viral loads in rhesus macaques. Importantly, in mosquito-infected animals ZIKV tissue distribution was limited to hemolymphatic tissues, ...[more]
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