Ontology highlight
ABSTRACT:
SUBMITTER: O'Connor MA
PROVIDER: S-EPMC6105614 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
O'Connor Megan A MA Tisoncik-Go Jennifer J Lewis Thomas B TB Miller Charlene J CJ Bratt Debra D Moats Cassie R CR Edlefsen Paul T PT Smedley Jeremy J Klatt Nichole R NR Gale Michael M Fuller Deborah Heydenburg DH
Nature communications 20180822 1
The immunological and virological events that contribute to the establishment of Zika virus (ZIKV) infection in humans are unclear. Here, we show that robust cellular innate immune responses arising early in the blood and tissues in response to ZIKV infection are significantly stronger in males and correlate with increased viral persistence. In particular, early peripheral blood recruitment of plasmacytoid dendritic cells and higher production of monocyte chemoattractant protein (MCP-1) correspo ...[more]