Ontology highlight
ABSTRACT:
SUBMITTER: Choquet H
PROVIDER: S-EPMC5727399 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Choquet Hélène H Thai Khanh K KK Yin Jie J Hoffmann Thomas J TJ Kvale Mark N MN Banda Yambazi Y Schaefer Catherine C Risch Neil N Nair K Saidas KS Melles Ronald R Jorgenson Eric E
Nature communications 20171213 1
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability. Here, we conduct a genome-wide association study of IOP in 69,756 untreated individuals of European, Latino, Asian, and African ancestry. Multiple longitudinal IOP measurements were collected through electronic health records and, in total, 356,987 measureme ...[more]