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Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides.

ABSTRACT: An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction.

SUBMITTER: Fan T 

PROVIDER: S-EPMC5727777 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides.

Fan Tao T   Meng Wei-Dong WD   Zhang Xingang X  

Beilstein journal of organic chemistry 20171206

An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction. ...[more]

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